Researchers from the Suzhou Institute of Biomedical Engineering and Technology have fabricated an ultrasensitive exosome biosensor based on a multipedal DNA walker with a core of target exosomes. Specific recognition is achieved by introducing a CD63 aptamer and facile separation is obtained with magnetic Fe3O4@Au nanoparticles. A limit of detection down to 6/μL is obtained with excellent selectivity.
Miao P, Tang Y. (2020) A multipedal DNA walker for amplified detection of tumor exosomes. Chem Commun (Camb) [Epub ahead of print]. [abstract]