Aethlon Medical, Inc, a therapeutic medical device and technology company focused on unmet needs in global health, announced today that it has received European Patent No. 1,993,600 (“the ‘600 Patent”) entitled “Extracorporeal Removal of Microvesicular Particles.” The ‘600 patent embodies Aethlon’s Hemopurifier® technology designed for the depletion of immune suppressive, and potentially cancer-promoting, exosomes from the circulatory system.
Exosomes have been shown to participate in the development and advancement of cancer. Exosomes derived from tumor cells may promote immune suppression and seed the spread of metastasis. Notably, these tumor derived exosomes may also inhibit the activity of immuno-oncology drugs such as pembrolizumab (KEYTRUDA®). Tumor derived exosomes are not currently addressed with an approved therapy.
Aethlon has demonstrated the ability of laboratory versions of the Hemopurifier® to capture exosomes underlying several forms of cancer, including breast, ovarian and melanoma, in laboratory experiments. In November 2018, Aethlon received a “Breakthrough Device” designation from the U.S. Food and Drug Administration (FDA) to support the advancement of the Hemopurifier® for the treatment of cancer. In October 2019, the FDA approved Aethlon’s Investigational Device Exemption (IDE) application to initiate an Early Feasibility Study (EFS) of the Hemopurifier® in patients with advanced head and neck cancer in combination with standard of care KEYTRUDA®. This EFS, which is the device equivalent of a phase 1 trial, will be a small single center, open label trial in 10 to 12 subjects.
“By reducing the presence of tumor-derived exosomes from the circulatory system of cancer patients, we believe the Aethlon Hemopurifier® could have the potential to improve the benefits of existing cancer treatment regimens and emerging immuno-oncology drugs,” stated Timothy C. Rodell, M.D., Aethlon’s CEO. “This issued European patent, along with corresponding issued patents in the United States and Canada, are critical for Aethlon’s plans to develop the Hemopurifier® for applications in oncology around the world.”
Source – PRNewswire