Nicole Noren Hooten from the National Institute on Aging at NIH contributes basic science research to the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) project, a long-term study of health disparities and aging in Baltimore, MD. Aging is the major risk factor for most chronic diseases. Dr. Noren Hooten discusses here how non-coding RNAs and extracellular vesicles (EVs) in the blood change with age, and future prospects for how knowledge about exRNA and EVs will impact our understanding of aging and its contribution to disease. This web seminar was presented as part of the Extracellular RNA Communication Consortium (ERCC) seminar series.