Reading Room

Pop open any college biology textbook from the early 1990s. Move over to the textbook’s index and search for “exosomes”. Flip to the right page....

The International Society for Extracellular Vesicles (ISEV) has organised its first educational online course for students and beginners in the field of extracellular vesicles (EVs). This course, “Basics of Extracellular Vesicles,” uses recorded lectures from experts in the field and ...

A growing number of researchers and some biotech companies are exploring ways to use tiny vesicles called exosomes, which are released into the blood by cells, to gain insights into cancer and to develop clinical tools for patients. Recent studies ...

from Genetic Engineering News by Michael Tackett, Graeme Doran, Daniel Pregibon Particle-Based Approach Profiles Up to 68 miRNAs from Plasma, Serum, and Exosomes MicroRNA (miRNA) profiling has tremendous potential for the diagnosis and prognosis of a broad range of diseases ...

This review focuses of the transcriptome (RNA) of these extracellular vesicles. Based on current data, these vesicular components play essential roles as conveyers of intercellular communication and mediators of many of the pathological conditions associated with cancer development, progression and ...

Many aspects of intercellular communication are mediated through “sending” and “receiving” packets of information via the secretion and subsequent receptor-mediated detection of biomolecular species including cytokines, chemokines, and even metabolites. Recent evidence has now established a new modality of intercellular ...

The development of human cancers is a multistep process in which normal cells acquire characteristics that ultimately lead to their conversion into cancer cells. Many obstacles must be overcome for this process to occur; of these obstacles, is the ability ...

Nuclease resistant extracellular miRNAs have been found in all known biological fluids. The biological function of extracellular miRNAs remains questionable; however, strong evidence suggests that these miRNAs can be more than just byproducts of cellular activity. Some extracellular miRNA species ...

Exosomes and microvesicles are extracellular nanovesicles released by most but not all cells. They are specifically equipped to mediate intercellular communication via the transfer of genetic information, including the transfer of both coding and non-coding RNAs, to recipient cells. As ...

from Genetics Engineering News – Exploring Exosomal RNA – Jun 15, 2013 (Vol. 33, No. 12) by Michael D. O’Neil Tiny, subcellular membrane-bound vesicles called exosomes are periodically released by a wide variety of cell types, carrying along with them ...