New research shows that mesenchymal stromal cells exosomes (MEx) can prevent preeclampsia in pre-clinical mouse models, likely through changing the intrauterine environment. This image shows uptake of MEx (red) into mouse uterine cells (blue). (Image: Elizabeth Taglauer, Boston Children’s Hospital) ...
Read More »The microfluidic toolbox for analyzing exosome biomarkers
As the fields of aging and neurological disease expand to liquid biopsies, there is a need to identify informative biomarkers for the diagnosis of neurodegeneration and other age-related disorders such as cancers. A means of high-throughput screening of biomolecules relevant ...
Read More »Identification of a novel RNA aptamer that selectively targets breast cancer exosomes
Breast cancer is a leading cause of cancer mortality in women. Despite advance in its management, the identification of new options for early stage...
Read More »Capricor Therapeutics Announces Publication Demonstrating Methods for Enhanced Potency of Cardiosphere-Derived Exosomes
Capricor Therapeutics, a clinical-stage biotechnology company focused on the discovery, development and commercialization of first-in-class cell- and exosome-based therapeutics for the treatment and...
Read More »Functional single-cell profiling identifies that exosomes are associated with increased immune cell infiltration in non-metastatic breast cancer
Exosomes mediate intercellular communication in health and disease. Conventional assays are limited in profiling exosomes secreted from large populations of cells and are unsuitable for studying the functional consequences of individual cells exhibiting varying...
Read More »Liquid biopsy-based exo-oncomiRNAs can predict prostate cancer aggressiveness
Liquid biopsy-based biomarkers, including microRNAs packaged within extracellular vesicles, are promising tools for patient management. The cytokine tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is related to PCa progression and is found in the semen of patients with PCa. ...
Read More »FT-IR spectroscopy to show alterations in molecular composition of EV subpopulations from melanoma cell lines in different malignancy
Melanoma cells release extracellular vesicles (EVs) subpopulations which differ in size, phenotype and molecular content. Melanoma derived EVs play a role...
Read More »Evaluation of exosome proteins by on-bead flow cytometry
Exosomes, recently re‐named “small extracellular vesicles” or “sEV,” are emerging as an intercellular communication system. Quantification of the molecular cargo exosomes carry by on‐bead flow...
Read More »Trends in Research on Exosomes in Cancer Progression and Anticancer Therapy
Exosomes, the endosome-derived bilayered extracellular nanovesicles with their contribution in many aspects of cancer biology, have become one...
Read More »Acoustofluidic centrifuge for nanoparticle enrichment and separation
Liquid droplets have been studied for decades and have recently experienced renewed attention as a simplified model for numerous fascinating physical...
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