Most cancer diagnostic techniques rely on uncomfortable and invasive procedures, such as biopsies, endoscopies or mammograms. Blood samples could be a less unpleasant option, though...
Read More »ExoSponge – rapid, cost-effective, porous polydimethylsiloxane (PDMS) based cancer-associated extracellular vesicle isolation
Polydimethylsiloxane (PDMS) is an inexpensive robust polymer that is commonly used as the fundamental fabrication material for soft-lithography-based microfluidic devices. Owing to its versatile...
Read More »Technological challenges of biomembrane-coated top-down cancer nanotherapy
Cancer nanotherapy suffers from low-yield delivery that is imposed by tumour pathophysiological barriers. Top-down drug delivery strategies, including exosomes and cell membrane-coated particles, can improve safety and efficacy owing to the innate biointerfacial properties of these platforms. Researchers at Universidade ...
Read More »Isolation and characterisation of exosomes from Chinese hamster ovary (CHO) cells
Exosomes have previously been isolated from Chinese hamster ovary (CHO) cells and their anti-apoptotic properties reported. However, to further...
Read More »Cell-Based Drug Delivery Systems with Innate Homing Capability as a Novel Nanocarrier Platform
Nanoparticle-based drug delivery systems have been designed to treat various diseases. However, many problems remain, such as inadequate tumor...
Read More »Extracellular vesicles – the next generation in gene therapy delivery
Extracellular vesicles (EVs) are esteemed as a promising delivery vehicle for various genetic therapeutics. They are relatively inert, non-immunogenic, biodegradable, and biocompatible...
Read More »Cellular messengers improve cancer therapy
Nano-sized membrane bubbles known as extracellular vesicles activate the immune system in mice and seem to render their tumours sensitive to a type of immunotherapy drug called a checkpoint...
Read More »Single-cell transcriptomics reveal extracellular vesicles secretion with a cardiomyocyte proteostasis signature during pathological remodeling
Aberrant Wnt activation has been reported in failing cardiomyocytes. Researchers at University Medical Center Göttingen present single cell transcriptome profiling of hearts with inducible cardiomyocyte-specific Wnt activation (β-catΔex3) as well as with...
Read More »Triple study exploits cellular messengers for diagnostics and drug delivery
In a series of three papers on extracellular vesicles (EVs) — particles that cells use to communicate — Skoltech researchers and their colleagues have...
Read More »Nanoscopic tool assesses alternative COVID-19 prevention
Researchers at Kanazawa University report in Nano Letters how high-speed atomic force microscopy can be used to assess the effectivity of spike-neutralizing antibodies for preventing COVID-19. The use of...
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