Bacterial extracellular vesicles (BEVs), including outer membrane vesicles, have emerged as a promising new class of vaccines and therapeutics to treat cancer and inflammatory diseases, among...
Read More »TurboID-EV – Proteomic Mapping of Recipient Cellular Proteins Proximal to Small Extracellular Vesicles
Extracellular vesicles (EVs), including exosomes, have been recognized as key mediators of intercellular communications through donor EV and recipient cell interaction. Until now, most studies...
Read More »Ion exchange chromatography as a simple and scalable method to isolate biologically active small extracellular vesicles from conditioned media
In the last few years, extracellular vesicles (EVs) have become of great interest due to their potential as biomarkers, drug delivery systems, and, in...
Read More »Rapid generation of functional nanovesicles from human trophectodermal cells for embryo attachment and outgrowth
Extracellular vesicles (EVs) are important mediators of embryo attachment and outgrowth critical for successful implantation. While EVs have garnered immense interest in their therapeutic potential in...
Read More »Selective enrichment of plasma cell-free messenger RNA in cancer-associated extracellular vesicles
Extracellular vesicles (EVs) have been shown as key mediators of extracellular small RNA transport. However, carriers of cell-free messenger RNA...
Read More »Dual-wave acoustofluidic centrifuge for ultrafast concentration of nanoparticles and extracellular vesicles
Extracellular vesicles (EVs) are secreted nanostructures that play various roles in critical cancer processes. They operate as an intercellular communication system, transferring complex sets of...
Read More »In situ capturing and counting device for the specific depletion and purification of cancer-derived exosomes
From metabolic waste to biological mediators, exosomes have emerged as the key player in a variety of pathological processes, particularly in oncogenesis. The exosome-mediated communication...
Read More »Phenotypic characterization of acoustically enriched extracellular vesicles from pathogen-activated platelets
Extracellular vesicles (EVs) are derived from the membrane of platelets and released in the circulation upon activation or injury. Analogous to the parent cell, platelet derived EVs play an important role in hemostasis and immune responses by transfer of bioactive ...
Read More »Quantitative and functional characterisation of extracellular vesicles after passive loading with hydrophobic or cholesterol-tagged small molecules
Extracellular vesicles (EVs) are nanosized intercellular messengers that bear enormous application potential as biological drug delivery vehicles. Much progress has been made for loading or decorating EVs with proteins, peptides or RNAs using genetically...
Read More »Modeling and optimization of parallelized immunomagnetic nanopore sorting for surface marker specific isolation of extracellular vesicles from complex media
The isolation of specific subpopulations of extracellular vesicles (EVs) based on their expression of surface markers poses a significant challenge due to their nanoscale size (< 800 nm), their heterogeneous surface marker expression, and the vast number of background EVs ...
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