Extracellular vesicles (EV) are a promising therapeutic tool in regenerative medicine. These particles were shown to accelerate wound healing, through delivery of regenerative mediators, such as microRNAs. Researchers at Exogenus Therapeutics describe an optimized and upscalable process for the isolation ...
Read More »Carbon-Dot-Enhanced Graphene Field-Effect Transistors for Ultrasensitive Detection of Exosomes
Graphene field-effect transistors (GFETs) are suitable building blocks for high-performance electrical biosensors, because graphene inherently exhibits a strong response to charged biomolecules...
Read More »Isolation and characterization of extracellular vesicles produced by cell lines
Cells produce two broad classes of extracellular vesicles (EVs), exosomes and microvesicles (MVs). Exosomes are 30–150 nm vesicles derived from...
Read More »On‐chip biogenesis of circulating natural killer cell‐derived exosomes
As the recognition between natural killer (NK) cells and cancer cells does not require antigen presentation, NK cells are being actively studied for use in adoptive cell therapies in the rapidly evolving armamentarium of cancer immunotherapy. In addition to utilizing ...
Read More »‘Golden’ exosomes as delivery vehicles to target tumors and overcome intratumoral barriers
Exosomes are promising vectors for anti-tumor therapy, due to their biocompatibility, low immunogenicity, and innate ability to interact with target cells. However, promoting clinical application of exosome-based therapeutics requires elucidation of key issues, including exosome biodistribution, tumor targeting and accumulation, ...
Read More »FT-IR spectroscopy to show alterations in molecular composition of EV subpopulations from melanoma cell lines in different malignancy
Melanoma cells release extracellular vesicles (EVs) subpopulations which differ in size, phenotype and molecular content. Melanoma derived EVs play a role...
Read More »Evaluation of exosome proteins by on-bead flow cytometry
Exosomes, recently re‐named “small extracellular vesicles” or “sEV,” are emerging as an intercellular communication system. Quantification of the molecular cargo exosomes carry by on‐bead flow...
Read More »Acoustofluidic centrifuge for nanoparticle enrichment and separation
Liquid droplets have been studied for decades and have recently experienced renewed attention as a simplified model for numerous fascinating physical...
Read More »Highly sensitive and stable self-powered biosensing for exosomes based on dual metal-organic frameworks nanocarriers
Biofuel cells (BFCs)-based self-powered biosensors suffer from the limited stability of bioenzymes. Meanwhile, the poor performance of self-powered biosensors affects the sensitivity of biosensing, thus...
Read More »Hyperspectral imaging-based exosome microarray for rapid molecular profiling of extracellular vesicles
One of the challenges of exploiting extracellular vesicles (EVs) as a disease biomarker is to differentiate EVs released by similar cell types or phenotypes. Researchers at Iowa State University have developed a high-throughput and label-free EV microarray technology to differentiate ...
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