Sorafenib is one of the few effective first-line drugs approved for the treatment of advanced hepatocellular carcinoma (HCC). However, the development of drug resistance is common among individuals with HCC. Recent evidence indicated that...
Read More »Fast and specific enrichment and quantification of cancer-related exosomes by DNA-nanoweight-assisted centrifugation
Exosomes are nanoscale membrane vesicles actively released by cells and play an important role in the diagnosis of cancer-related diseases. However, it is challenging to efficiently enrich exosomes from...
Read More »SARS-CoV-2 and mitochondrial proteins in neural-derived exosomes of COVID-19
As SARS-CoV-2 is known to invade neural cell mitochondria, researchers at UCSF investigated neuropathogenic mechanisms of long-COVID-19...
Read More »An in situ strategy for labelling exosome proteins using engineered ascorbate peroxidase APEX
The extracellular vesicle exosome mediates intercellular communication by transporting macromolecules such as proteins and ribonucleic acids (RNAs). Determining cargo contents with high...
Read More »A tri-channel electrochemical immunobiosensor for combined detections of multiple exosome biomarkers of lung cancer
Current methods for the early diagnosis of cancer can be invasive and costly. In recent years, exosomes have been recognized as potential biomarkers for cancer diagnostics. The common methods...
Read More »Urinary extracellular vesicles and micro-RNA as markers of acute kidney injury after cardiac surgery
University of Leicester researchers hypothesised that measuring changes in urinary levels of EV and miR will predict the onset of acute kidney injury in...
Read More »Heparin affinity chromatography for extracellular vesicle purification and fractionation
The purification of extracellular vesicles (EVs) remains a major hurdle in the progression of fundamental research and the commercial...
Read More »Researchers develop hybrid sensor that can help diagnose cancer
A team of researchers from HSE University, Skoltech, MPGU, and MISIS have developed a nanophotonic-microfluidic sensor whose potential applications include cancer detection, monitoring and treatment..
Read More »Engineering extracellular vesicles by three-dimensional dynamic culture of hMSC
Human mesenchymal stem cell (hMSC) derived extracellular vesicles (EVs) have shown therapeutic potential in recent studies. However, the corresponding therapeutic components are largely unknown, and scale-up production of hMSC EVs is a major challenge for translational applications. Researchers at Florida ...
Read More »A bimodal liquid biopsy for cancer immunotherapy
Despite its high potential, PD-L1 expressed by tumors has not been successfully utilized as a biomarker for estimating treatment responses to immunotherapy. Circulating tumor cells and...
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