Cancer nanotherapy suffers from low-yield delivery that is imposed by tumour pathophysiological barriers. Top-down drug delivery strategies, including exosomes and cell membrane-coated particles, can improve safety and efficacy owing to the innate biointerfacial properties of these platforms. Researchers at Universidade ...
Read More »Cell-Based Drug Delivery Systems with Innate Homing Capability as a Novel Nanocarrier Platform
Nanoparticle-based drug delivery systems have been designed to treat various diseases. However, many problems remain, such as inadequate tumor...
Read More »Extracellular vesicles – the next generation in gene therapy delivery
Extracellular vesicles (EVs) are esteemed as a promising delivery vehicle for various genetic therapeutics. They are relatively inert, non-immunogenic, biodegradable, and biocompatible...
Read More »DNA Nanomaterial-Based Optical Probes for Exosomal miRNA Detection
Micro ribonucleic acids (miRNAs) in exosomes have been proven as reliable biomarkers to detect disease progression. In recent years, deoxyribonucleic acid...
Read More »The Machinery of Exosomes: Biogenesis, Release, and Uptake
Exosomes are a subtype of membrane-contained vesicles 40–200 nm in diameter that are secreted by cells into their surroundings. By transporting proteins, lipids, mRNA, miRNA, lncRNA, and DNA...
Read More »Recent advances in extracellular vesicle-based organic nanotherapeutic drugs for precision cancer therapy
Due to the critical limitations of conventional antitumor agents, great efforts have been made to develop advanced drug delivery systems to enhance the therapeutic outcomes of antitumor drugs, reduce...
Read More »Functions and therapeutic potentials of exosomes in osteosarcoma
Osteosarcoma, a primary malignant tumor of the skeleton, has a morbidity of 2.5 per 1 million people. The epiphysis of extremities is typically affected...
Read More »Can exosomes transfer the preconditioning effects triggered by (poly)phenol compounds between cells?
Effective strategies in prolonging life- and health span are increasingly recognized as acting as mild stressors. Micronutrients and other dietary compounds such as (poly)phenols may act as moderate...
Read More »Exosome-driven liquid biopsy for breast cancer
Liquid biopsy with minimally invasive emerges as a powerful tool for early screening of breast cancer (BrCa). BrCa derived exosomes which enrich with biological information from their parent cells play essential roles in the evolution and metastasis of BrCa, providing ...
Read More »Analysis and biomedical applications of functional cargo in extracellular vesicles
Extracellular vesicles (EVs) can facilitate essential communication among cells in a range of pathophysiological conditions including cancer metastasis and progression, immune regulation, and neuronal communication. EVs are membrane...
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