Clinical Impact of Multi-omics profiling of extracellular vesicles in cancer Liquid Biopsy

Multi-Omics exosomes profiling-based liquid biopsy develops a smart platform for cancer early detection. This method addresses several complications in exosome research such as exosome origin, exosome molecular cargo profiling, and molecular diversity. It supports specific cancer theranostics development. This article highlighted the clinical impact of exosomes in cancer, the advantages, limitations of muti-omics profiling, and the Future improvement of this method.

The landscape of omics analysis

2-DE, 2-Dimensional Electrophoresis; ATAC, Assay for Transposase-Accessible Chromatin; CAGE, Cap Analysis Gene Expression; DNMT1, DNA Methyl Transferase one; ESI, Electrospray Ionization; EST, Expressed Sequence Tags; GC, Gas Chromatography; HAT, Histone Acetyl Transferase; HDAC, Histone Deacetylase; Hi-C, High-throughput Chromosome Conformation Capture; HPLC, High Performance Liquid Chromatography; IMAC, Immobilized Metal Affinity Chromatography; iTRAQ, Isobaric Tags for Relative and Absolute Quantitation; LC, Liquid Chromatography; MALDI, Matrix-Assisted Laser Desorption/Ionization; MeDIP, Methylated DNA Immunoprecipitation; MPSS, Massively Parallel Signature Sequencing; MS, Mass spectrometry; NGS, Next Generation Sequencing; PCR, Polymerase Chain Reaction; SAGE, Serial Analysis of Gene Expression; Sc-RNA, Single cell RNA; SILAC, Stable Isotope Labeling with Amino acids in Cell culture; T2T, Telomere-To-Telomere 

Kulkarni M, Kar R, Ghosh S, Sonar S, Mirgh D, Sivakumar I, Nayak A, Muthusamy R. (2024) Clinical Impact of Multi-omics profiling of extracellular vesicles in cancer Liquid Biopsy. J Liquid Biopsy [Epub ahead of print]. [article]

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