EVPsort – an atlas of small ncRNA profiling and sorting in extracellular vesicles and particles

A new interactive tool presents information on noncoding RNA in extracellular vesicles — agents of cell-cell communication that may have a future in medical diagnosis and therapeutics.

Researchers at the Vanderbilt University Medical Center have developed EVPsort, a powerful tool designed to unravel the mysteries of ncRNA abundance and sorting mechanisms within EVPs. This innovative database offers a comprehensive overview of ncRNA profiling, drawing from an extensive collection of 3,162 samples obtained from various biofluids, cell lines, and disease contexts.

One of EVPsort’s standout features is its seamless integration with 19 external databases and tools, enriching its capabilities and enhancing the depth of analysis. By incorporating information on associations between ncRNAs and RNA-binding proteins (RBPs), motifs, targets, pathways, diseases, and drugs, EVPsort provides researchers with a wealth of resources to explore and understand ncRNA biology.

EVPsort’s sophisticated analysis tools enable researchers to explore ncRNA sorting within EVPs, identifying relevant RBPs and motifs that govern this process. Furthermore, the database allows for the assessment of functional implications, shedding light on the role of ncRNAs in disease pathogenesis and potential therapeutic targets.

By offering a comprehensive platform for investigating both the abundance and sorting of ncRNA within EVPs, EVPsort paves the way for advancements in our understanding of cell-to-cell communication and opens new avenues for clinical applications.

As researchers continue to unlock the secrets hidden within EVPs and ncRNAs, tools like EVPsort will play a vital role in accelerating discoveries and driving progress in biomedical research. With its rich resources and powerful analysis capabilities, EVPsort empowers scientists to unravel the complexities of cellular communication and unlock the potential of extracellular vesicles in health and disease.

Availability – It is freely accessible at https://bioinfo.vanderbilt.edu/evpsort/.

Chen HC, Wang J, Coffey RJ, Patton JG, Weaver AM, Shyr Y, Liu Q. (2024) EVPsort: An Atlas of Small ncRNA Profiling and Sorting in Extracellular Vesicles and Particles. J Mol Biol [Epub ahead of print]. [article]

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