Exosomal microRNAs improve behavior, motor function in Rett mouse model

Fig. 7

The exosomal miR-21-5p of USCs promoted early neural formation by regulating EPha4/TEK axis to promote the differentiation of NSCs in RTT.

From Rett Syndrome News

Rett syndrome is primarily caused by mutations in the MECP2 gene that affect the brain and result in cognitive, sensory, emotional, and motor disturbances, as well as difficulties with breathing, the heart, and digestion.

The use of microRNA molecules that targeted a protein receptor important for nerve cell growth led to improved behaviors and motor function in a Rett syndrome mouse model, a study shows.

These molecules were carried by tiny vesicles called exosomes, which were derived from human urinary stem cells.

The findings support further development of this strategy to improve brain function and movement in people with Rett, the researchers said…

Pan W, Xu X, Zhang M, Song X. (2021) Human urine-derived stem cell-derived exosomal miR-21-5p promotes neurogenesis to attenuate Rett syndrome via the EPha4/TEK axis. Lab Invest 101(7):824-836. [abstract]

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