Metastasis, a critical phase of tumor progression, remains a primary challenge in treating cancer and a major cause of cancer mortality. Cell-cell communication via extracellular vesicles (exosomes and microvesicles) between primary tumor cells and the microenvironment of distant organs is crucial for pre-metastatic niche (PMN) formation and metastasis. Weill Cornell Medicine researchers review work on the contribution of exosome cargo to cancer progression, the role of exosomes in PMN establishment, and the function of exosomes in organotropic metastasis. They also describe the clinical utility of exosomes.
Exosome-Mediated Metastasis – Communication from a Distance
Wortzel I, Dror S, Kenific CM, Lyden D. (2019) Exosome-Mediated Metastasis: Communication from a Distance. Dev Cell 49(3):347-360. [article]