Exosomes are small extracellular vesicles with a significant role in most processes associated with cancer. On one hand, exosomes role in the different hallmarks of cancer has been widely described, highlighting the urge to understand the potential to target communication mediated by exosomes as a novel therapeutic approach in cancer. On the other hand, exosomes stability in circulation and tumor-targeting capacity shows their applicability in the delivery of anti-cancer molecules. Researchers from the University of Porto discuss the dual applicability of exosomes in cancer focusing on their usage for therapy improvement, or their targeting to block their supportive role in tumor progression and response to therapy. They highlight the current developments and the strategies used to enhance the potential of exosomes to become clinical partners in the treatment of cancer.
Exosomes in cancer: Use them or target them?
Bastos N, Ruivo CF, da Silva S, Melo SA. (2018) Exosomes in cancer: Use them or target them? Sem in Cell & Dev Biol 78(1):13-21. [abstract]