Extracellular RNA – Emerging roles in cancer cell communication and biomarkers

Extracellular RNAs (exRNAs) are a type of RNA molecules that present in various biological fluids. exRNAs are heterogenous populations including small (e.g., miRNA) and long non-coding RNAs and coding RNAs (e.g., mRNA). They can exist in a free form or associate with carriers range from lipo- and ribo-proteins to extracellular vesicles such as exosomes in the extracellular fluids. exRNAs participate in cell-to-cell communication to regulate a broad array of physiological and pathological processes. exRNAs have been widely studied as a biomarker for cancer and other diseases. Researchers at Sungkyunkwan University discuss the sorts of exRNAs with potential carriers as well as their roles in cancer.

Author links open overlay panel Kim S, Jeon OH, Jeon YJ. (2020) Extracellular RNA: Emerging roles in cancer cell communication and biomarkers. Cancer Letters [online ahead of print]. [abstract]

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