Extracellular vesicle-mediated modulation of angiogenesis

Angiogenesis is a tightly regulated process where a number of different players are involved. Recently, a role for membrane vesicles actively released from cells has been proposed. Virtually all cell types may release non-apoptotic membrane vesicles in the nano-size range containing critical components of the cell of origin. The two main categories of these vesicles include exosomes and microvesicles that differ for biogenesis but, sharing several features and mechanisms of action, have been collectively named extracellular vesicles (EV). EV are able to transfer from one cell to another bioactive lipids, proteins and nucleic acids that may induce changes in the phenotype and functions of the recipient cells. This new mechanism of cell to cell communication has been involved in modulation of the angiogenic process. Tumor cells, inflammatory cells and stem/progenitor cells were shown to release EV with angiogenic properties suggesting that they may act on vascular remodeling in different physiological and pathological conditions.

exosome rna

Angiogenic potential of EV. EV by delivering their cargo to endothelial cells may be involved in angiogenic homeostasis, in the angiogenesis associated with tissue repair and in the altered angiogenesis occurring in tumors and inflammation.

Gai C, Carpanetto A, Deregibus MC, Camussi G. (2015) Extracellular vesicle-mediated modulation of angiogenesis. Histol Histopathol [Epub ahead of print]. [abstract]

Leave a Reply

Your email address will not be published. Required fields are marked *