Extracellular vesicle studies – From benchtop to therapeutics

Extracellular vesicles are secreted, membrane-bound compartments containing DNA and cytoplasmic constituent molecules of all types that are thought to act as mediators of intercellular communication. They are classified by both size and location/mechanism of cellular origination. They are thought to be produced by an ever-expanding diversity of cell types and species. However, there is also considerable skepticism related to their existence and utility, as it can be difficult to isolate EVs since there is no EV-specific molecular marker to target.

A primary focus in recent years has been to describe the mechanisms of molecular sorting that would allow researchers to target proteins produced from exogenously introduced DNA to EVs for cellular secretion and uptake. The potential value of EVs to therapeutics is thought to be enormous, thanks to the role of EVs in cell–cell communication as a robust, native delivery vehicle.

This event will appeal to a broad audience, including molecular biologists, biochemists, biophysicists, secretion experts, cell–cell communication specialists, clinicians, physiologists and others.