During the past decades, EVs have emerged as attractive drug delivery systems. Here, a team led by researchers at University Medical Center Utrecht assess their pre-clinical applications, in the form of a systematic review. For each study published during the past decade, disease models, animal species, EV donor cell types, active pharmaceutical ingredients (APIs), EV surface modifications, API loading methods, EV size and charge, estimation of EV purity, presence of biodistribution studies and administration routes were qualitatively analyzed in a defined and reproducible way. The researchers have interpreted the trends they observe over the past decade, to define the niches where to apply EVs for drug delivery in the future and to provide a basis for regulatory guidelines.
Extracellular vesicles as a drug delivery system
Escudé Martinez de Castilla P, Tong L, Huang C, Marios Sofias A, Pastorin G, Chen X, Storm G, Schiffelers RM, Wang JW. (2021) Extracellular vesicles as a drug delivery system:A systematic review of preclinical studies. Adv Drug Deliv Rev [Epub ahead of print]. [abstract]