Extracellular vesicles can be isolated from CF patients’ blood

A recent study led by researchers at Children’s Health Ireland investigated the presence of extracellular vesicles (EVs) in the blood of patients with cystic fibrosis (CF). EVs are small membrane-bound particles that are released by cells and play a role in intercellular communication. Previous research has suggested that EVs may be involved in the pathogenesis of CF.

The study found that EVs were present in the blood of CF patients at higher levels than in healthy controls. The researchers also isolated two types of EVs – exosomes and microvesicles – from the blood of CF patients and identified the proteins and RNAs that were present in them. They found that the EVs from CF patients contained higher levels of certain proteins and RNAs that are known to be involved in inflammation and immune response.

The researchers suggest that the presence of these EVs and their contents may contribute to the chronic inflammation and lung damage that are characteristic of CF. They also propose that EVs may serve as biomarkers for CF and could be used to monitor disease progression or response to treatment.

Overall, this study sheds light on the role of EVs in CF and suggests that they may be a promising target for future research and therapeutic development.

SourceCystic Fibrosis News

Trappe A, Lakkappa N, Carter S, Dillon E, Wynne K, McKone E, McNally P, Coppinger JA. (2023) Investigating serum extracellular vesicles in Cystic Fibrosis. J Cyst Fibros [Eub ahead of print.]. [article]

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