Extracellular vesicles could help prevent amputations in diabetic patients

From Advanced Science News by Victoria Corless 

This safer, non-surgical treatment for diabetic limb ischemia could help patients with severe blood flow complications.

Scientists are making strides toward a potential new treatment for diabetic limb ischemia, a common and serious complication of diabetes. This condition, marked by reduced blood flow to the legs and feet, can result in chronic pain, stubborn ulcers, and, in severe cases, limb amputation — and is currently the leading cause of non-traumatic amputations…

Extracellular vesicles

An emerging therapy is based on extracellular vesicles, which are lipid bound particles that carry biomolecules and are naturally released from almost all types of cells.

“Extracellular vesicle transplantation, particularly exosome transplantation, offers several advantages over traditional stem cell transplantation,” wrote the team in their paper, as they overcome all the barriers posed by stem cell therapy.

A critical step in extracellular vesicle therapy is identifying a protein or gene that can guide the vesicles and enhance their effectiveness for treating the target disease because these proteins or genes help direct the vesicles to the specific cells or tissues that need treatment…

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