Extracellular Vesicles in Prostate Cancer: Multi-Omic Liquid Biopsy

in Presentations July 31, 2024

Andrea Miyahira discusses with Irene Casanova-Salas and Joaquin Mateo a Cancer Cell publication on using circulating tumor extracellular vesicles (EVs) to monitor metastatic prostate cancer evolution. The researchers describe their novel method for analyzing both DNA and RNA from EVs in patient plasma samples. They highlight the advantages of EV analysis over traditional ctDNA, including the ability to capture transcriptomic changes and early treatment adaptations. The study demonstrates that EV profiling can recapitulate tumor features, associate with disease progression, and indicate early tumor adaptation to therapy. The researchers discuss the potential of EV analysis for patient stratification, particularly in identifying neuroendocrine features. They emphasize the challenges of EV heterogeneity and the need for further validation in larger cohorts. Future work will focus on expanding the application of this technique and exploring functional aspects using PDX models.

Source – UroToday

Casanova-Salas I, Aguilar D, Cordoba-Terreros S, Agundez L, Brandariz J, Herranz N, Mas A, Gonzalez M, Morales-Barrera R, Sierra A, Soriano-Navarro M, Cresta P, Mir G, Simonetti S, Rodrigues G, Arce-Gallego S, Delgado-Serrano L, Agustí I, Castellano-Sanz E, Mast R, de Albert M, Celma A, Santamaria A, Gonzalez L, Castro N, Suanes MDM, Hernández-Losa J, Nonell L, Peinado H, Carles J, Mateo J. (2024) Circulating tumor extracellular vesicles to monitor metastatic prostate cancer genomics and transcriptomic evolution. Cancer Cell 42(7):1301-1312.e7. [article]