Location – Italy
Posted – November 28 2017
In the present project we would like to characterize the content of exosomes, in terms of proteins and RNAs, to understand the molecular mechanisms underlying the neuroprotective effect that we have assessed in vitro. Moreover, we would like to investigate the possible neuroprotective effect of exosomes treatment in a murine model of ALS, the SOD1 (G93A) animals (mSOD1), as a possible new ALS therapeutic approach. In addition, we will evaluate the differential gene expression in target tissues of mSOD1 exosomes treated, mSOD1 untreated and wild-type animals. The analysis of gene expression could help to understand how exosomes can alter the gene expression of cells target and to identify some ALS biomarker.