Featured Exosome Job – Sr Scientist, Exosomes

We are seeking for a highly motivated scientist with experience in extracellular vesicles (i.e. exosome) isolation and characterization to join the Oncology Translational Research team in GSK. The Oncology Translational Research team will partner with Oncology TA team members increase clinical translatability and to contribute to preclinical development programmes within GSK Oncology TA. The successful candidate will work as part of a team that, by exploiting patient-derived explants/derivatives, is developing and implementing cutting-edge cellular, genomic and molecular techniques with a multimodality analytic approach, plus machine learning models to improve cancer patient risk stratification as well as to predict future targeted and/or immuno-therapy susceptibilities.

Key Responsibilities

  • Setting up cell protocols for exosomes isolation and characterization from patient-derived explants/derivatives
  • Purify exosomes from the cell culture medium using ultracentrifugation or related method, and related process development and optimization
  • Developing protocols and conducting experiments for analysis of RNA, DNA length and DNA preparation for sequencing
  • Developing protocols and conducting experiments for analysis of proteins isolated from exosomes (dot-blot, flow cytometry assay, proteomics including mass spectrometry, Reverse-phase protein array (RPPA))
  • Collecting and reporting data to the  Director – Multiomics Patient Derived Explant/ derivatives.
  • Interacting with and managing the other (more junior) team members to define the panel of multimodality (DNA/RNA/Protein) markers to be evaluated, in accordance with the mechanisms of action.
  • Execute and deliver data of the project to a high quality and within define timeframes
  • Solve technical issues operate as part of a cross-functional project team
  • Collaborate with Oncology Clinical Development, Project Leadership and Research Unit teams

Closing Date for Applications: 15th December 2023 (COB)

Please take a copy of the Job Description, as this will not be available post closure of the advert.

When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above.

The information that you have provided in your cover letter and CV will be used to assess your application.

Basic Qualifications

  • BSc or MSc in Cell Biology/Oncology or related , with extensive research experience
  • A multidisciplinary mix of training/expertise in cellular biology, oncology as well as integrative data analysis.
  • Significant experience in extracellular vesicles and in particular exosomes characterization.
  • Cellular Biology skills: extracellular vesicle isolation and characterization; cultures of normal and tumour cells from primary samples or immortalized cell lines.
  • Molecular biology skills: nucleic acid extraction; in vitro cell assay (western blot, MTT, cell titre glow, protein quantification); sequencing (gene and/or protein) related to extracellular vesicles.
  • Experience with Extracellular Vesicles research
  • A strong track record of scientific Publications in the relevant area
  • Ability to communicate with team members from different backgrounds by training/discipline, as well as senior members of the GSK stakeholders/research partner units
  • Ability to deliver high quality, consistent results in a timely fashion with a positive can-do and result oriented attitude
  • Prior experience of managing or supervising (more) junior members in a laboratory

Preferred Qualifications 

  • Previous pharmaceutical or biotechnology industry research experience working on drug discovery project teams.
  • Experience of flow cytometry
  • A track record of scientific Publication
  • Strong understanding of cancer biology, including the molecular mechanisms underlying tumorigenesis and cancer progression
  • Excellent leadership and communication skills
  • Strong strategic thinking and problem-solving skills, with the ability to navigate complex scientific and business challenges

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