Generation, Purification and Engineering of Extracellular Vesicles and Their Biomedical Applications.

Extracellular vesicles (EVs), derived from cell membranes, demonstrate the potential to be excellent therapeutics and drug carriers. Although EVs are promising, the process to develop high-quality and scalable EVs for their translation is demanding. Within this research, Washington State University researchers analyzed the production of EVs, their purification and their post-bioengineering, and they also discussed the biomedical applications of EVs. The researchers focus on the developments of methods in producing EVs including biological, physical, and chemical approaches. Furthermore, they discuss the challenges and the opportunities that arose when they translated EVs in clinic. With the advancements in nanotechnology and immunology, genetically engineering EVs is a new frontier in developing new therapeutics in order to tailor to individuals and different disease stages in treatments of cancer and inflammatory diseases.