Human Placenta Exosomes: Biogenesis, Isolation, Composition, and Prospects for Use in Diagnostics

Exosomes are 40-100 nm nanovesicles participating in intercellular communication and transferring various bioactive proteins, mRNAs, miRNAs, and lipids. During pregnancy, the placenta releases exosomes into the maternal circulation. Placental exosomes are detected in the maternal blood even in the first trimester of pregnancy and their numbers increase significantly by the end of pregnancy. Exosomes are necessary for the normal functioning of the placenta and fetal development. Effects of exosomes on target cells depend not only on their concentration but also on their intrinsic components. The biochemical composition of the placental exosomes may cause various complications of pregnancy. Some studies relate the changes in the composition of nanovesicles to placental dysfunction. Isolation of placental exosomes from the blood of pregnant women and the study of protein, lipid, and nucleic composition can lead to the development of methods for early diagnosis of pregnancy pathologies. Researchers from the University of Nottingham describe the biogenesis of exosomes, methods of their isolation, analyze their biochemical composition, and consider the prospects for using exosomes to diagnose pregnancy pathologies.

EV-mediated intercellular communication in the central nervous system


Lizarraga-Valderrama LR, Sheridan GK. (2021) Extracellular Vesicles and Intercellular Communication in the Central Nervous System. FEBS Lett [Epub ahead of print]. [abstract]

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