Radio-resistance has always been a major obstacle in radiation therapy (RT) progress. Radiotherapy (RT) leads to changes in the contents of released exosomes. The research has shown that irradiated cell-derived exosomes influence recipient cell proliferation, migration, cell cycle arrest and apoptosis. All evidence indicates that exosomes play a significant role in radio-resistance. Sichuan University researchers describe the potential role of exosomes in cancer. They summarize that the irradiated cell-derived exosomes influence radio-resistance in recipient cells by three main mechanisms: 1) enhancing DNA repair, 2) regulating cell death signalling pathways, 3) inducing cancer cells to exhibit stem cell properties. The researchers also discuss that the origin of the phenomenon might be the changes of molecular mechanisms of irradiated cell-derived exosomes formation affected by RT. Further, targeting exosomes as an adjuvant therapy might be a promising way for cancer treatments.
Irradiated cell-derived exosomes transmit essential molecules inducing radiotherapy resistance
Li Y, Huang L, Chen Y, Shi Y, Ze Y, Yao Y. (2022) Irradiated cell-derived exosomes transmit essential molecules inducing radiotherapy resistance. Int J Rad Onc [Epub ahead of print]. [abstract]