from Genetic Engineering News by Enal Razvi and Gary Oosta
The field of liquid biopsies is rapidly expanding and evolving. Select Biosciences sought to map the dynamics of this evolution by analyzing the scientific literature that comprises not only the liquid biopsies space but also the ensemble of circulating biomarkers, which has given rise to liquid biopsies.
The expanding knowledge base in the circulating biomarkers field is comprised of circulating tumor cells (CTCs), circulating cell-free DNA (cfDNA), circulating RNA, circulating extracellular vesicles (EVs) as well as circulating proteins—each of these “component sub-fields” is expanding at different rates driven by a number of factors presented below:
- Composition of researchers focusing on a particular circulating biomarker class
- Types of technologies/tool being deployed
- Sample classes utilized—this is the domain of biofluids from which circulating biomarkers are harvested