Liquid biopsy analyses are already incorporated in the routine clinical practice in many hospitals and oncology departments worldwide, improving the selection of treatments and monitoring of lung cancer patients. Although they have not yet reached its full potential, liquid biopsy-based tests will soon be as widespread as “standard” biopsies and imaging techniques, offering invaluable diagnostic, prognostic, and predictive information. Researchers from the Quirón Dexeus University Hospital summarize the techniques available for the isolation and analysis of circulating free DNA and RNA, exosomes, tumor-educated platelets, and circulating tumor cells from the blood of cancer patients, presents the methodological challenges associated with each of these materials, and discuss the clinical applications of liquid biopsy testing in lung cancer.
Liquid Biopsy in Non-Small Cell Lung Cancer
Molina-Vila MA, Mayo-de-Las-Casas C, Giménez-Capitán A, Jordana-Ariza N, Garzón M, Balada A, Villatoro S, Teixidó C, García-Peláez B, Aguado C, Catalán MJ, Campos R, Pérez-Rosado A, Bertran-Alamillo J, Martínez-Bueno A, Gil MD, González-Cao M, González X, Morales-Espinosa D, Viteri S, Karachaliou N, Rosell R. (2017) Liquid Biopsy in Non-Small Cell Lung Cancer. Front Med (Lausanne) 3:69. [article]