MDimune Inc. and Evercyte GmbH announced a strategic collaboration to develop tumor-targeted drug delivery by combining MDimune’s BioDrone® platform technology based on cell-derived vesicles (CDVs) and Evercyte’s technology to modify surface proteins to create tumor-specific binding affinity.
The current collaborative effort is based on the highly expandable BioDrone® platform of MDimune which synergizes with Evercyte’s novel and proprietary technology platform for the generation of targeted extracellular vesicles (EVs), being developed in cooperation with BOKU (University of Natural Resources and Life Sciences Vienna / ACIB (Austrian Center of Industrial Biotechnolgy). This platform is based on the generation of a surface display library by randomization of an extracellular loop of EV surface proteins. Thereby, Evercyte can identify and isolate high-affinity binders to any surface molecule including specific tumor antigens, which then turns EVs, such as CDVs, into targeted drug delivery vehicles.
Seung Wook Oh, Ph.D., Chief Scientific Officer of MDimune emphasized that “the collaboration with Evercyte will provide an extremely interesting opportunity for MDimune to move forward to achieving selective drug delivery.“ “The superior productivity of CDVs, compared to other EVs such as exosomes, will surely facilitate the development of tumor-targeted drug delivery approach,” said Dr. Oh.
“By forming this partnership with MDimune, targeting of extracellular vesicles to tumors will open up new avenues of drug targeting to tumors or of EV targeting in general,” said Regina Grillari (CTO, Evercyte). “In combination with our telomerized human cell lines as standardized EV production systems and our cell-based assay services, we will contribute to paving the road for EVs and exosomes to clinics,” added Dr. Grillari.
Source – EINPressWire