MDPI journal Cells announces special issue – “Stem-Cell-Derived Extracellular Vesicles as Cargo for Biomolecules including Lipids, Proteins or RNA”

Special Issue Information

In addition to the conventional molecular secretome, cells secrete large amounts of extracellular vesicles (EVs). EV is “the generic term for a particle naturally released from the cell that is delimited by a lipid bilayer and cannot replicate, i.e. does not contain a functional nucleus” as endorsed by the International Society for Extracellular Vesicles (ISEV). EVs are known to be instruments of intercellular communication to exchange components between cells in normal homeostatic processes, and to contribute to pathological developments.  Stem cells including iPS cells, neural crest cells, and MSCs produce different types of EVs that may have distinct structural and biochemical properties depending on the cell source and intracellular site of origin. Based on the current knowledge of their biogenesis, EVs are broadly divided into two main categories: microvesicles and exosomes. Microvesicles are generated by the outward budding and fission of the plasma membrane and their subsequent release into the extracellular space. They usually comprise vesicles in the size range of 100–1000 nm. Exosomes are formed by the inward budding of the endosomal membrane during the maturation of multivesicular endosomes (MVE) and are secreted upon the fusion of MVE with the cell surface and their size is in the 50 to 150 nm range. Given the limitation in our ability to segregate EV subtypes by isolation techniques, the nomenclature proposed by ISEV uses the terms small EVs and large EVs for vesicles with a diameter lower or higher than 120–150 nm, respectively. Finally, molecules that constitute the EV cargoes are enriched in the forming vesicles by mechanisms of clustering and budding, followed by membrane scission for EV release. The nature and abundance of EV cargoes are cell-type-specific and often influenced by the physiological or pathological state of the parental cell, the stimuli that modulate their release, and the molecular machinery that leads to EV formation. However, a conserved range of proteins are found to be enriched in EVs compared to their parental cells, and EV cargo includes the tetraspanins, heat shock proteins, specific lipids such as phosphatidylserine (PS), sphingomyelin, RNAs (e.g., intact and fragmented messenger RNA, microRNA, transfer RNA, ribosomal RNA fragments, and long non-coding RNA).

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI’s English editing service prior to publication or during author revisions.


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