NeuroDex announced that it has received a second grant from The Michael J. Fox Foundation for Parkinson’s Research (MJFF), to study “Neuronal extracellular vesicles blood-based biomarker for lysosomal function.”This award will enable NeuroDex to utilize its unique ExoSORT™ platform to develop an extracellular vesicle (EV) based blood biomarker for lysosomal damage. The study will utilize an optimized procedure for neuron-derived EV (NDE) isolation to develop neuron-specific lysosomal dysfunction biomarkers.
Dr. Erez Eitan, PhD., Co-Founder and Chief Scientific Officer of NeuroDex stated, “Lysosome inhibition significantly increases EV secretion, and thus, we anticipate that EVs can be a biomarker of lysosomal function. In this study, we will test how EV-associated markers change in response to drugs that modulate autophagy and lysosome function in cell culture and human plasma.”
Mr. Oded Biran, the Company’s Co-Founder and CEO, stated, “We are proud to receive this additional funding from The Michael J. Fox Foundation, intended to advance the important mission of developing blood-based biomarkers for lysosomal damage.” Mr. Biran added, “We believe that this grant will help NeuroDex to support clinical trials in the emerging space of lysosome base therapeutics for neurodegenerative diseases like Parkinson’s.”
NeuroDex is a leading developer of exosome-of-origin-based diagnostics, theragnostic, prognostics, and pharmacodynamics. NeuroDex’s integrative research platform, called ExoSORT™ combines bioinformatics and state-of-the-art laboratory processes. Building on all its proprietary platform technologies (including ExoSORT™), NeuroDex develops a full range of exosome-of-origin, minimally invasive, blood-based diagnostics. For more information, visit https://neurodex.co.
Exosomes, also called Extracellular vesicles (EVs), are small, membrane-bound particles released by cells into the extracellular space. They play a role in intercellular communication and protein disposal and are involved in both physiological and pathological processes. Exosomes found in blood have been studied as potential diagnostic markers for a variety of diseases.
Source – EIN News