Usage and rate of increase of common EV terms in PubMed-indexed articles
A major focus of the recently updated guidelines of the International Society for Extracellular Vesicles (ISEV) on minimal information for studies of extracellular vesicles (MISEV) is the need for appropriate (that is, informative and effective) nomenclature in reporting extracellular vesicle (EV) research. The ISEV consensus recommendation on nomenclature is to use “extracellular vesicle” as the “generic term for particles naturally released from the cell that are delimited by a lipid bilayer and cannot replicate” and to modify “EV” based on clear, measurable characteristics such as cell of origin, molecular markers, size, density, function, etc. Much like the biological entity it describes, the term “EV” is a scaffold on which to place further defining characteristics. MISEV does not prohibit other terms but rather specifies that they be defined carefully at first use in a manuscript.