Diabetes may be a consequence of pancreatic cancer, preceding cancer diagnosis. The underlying mechanism is the release exosomes delivering adrenomedullin to β-cells, inducing endoplasmic reticulum stress and perturbations in the unfolded protein response, leading to β-cell dysfunction and death. This knowledge could lead to improved diagnostic strategies for pancreatic cancer.
Korc M. (2015) Pancreatic Cancer-Associated Diabetes Is an “Exosomopathy”. Clin Cancer Res [Epub ahead of print]. [abstract]