PhD candidate position available – detection of tumor-derived extracellular vesicles

Calling all aspiring researchers! Join our Department of Cell and Chemical Biology as a PhD student and delve into the fascinating world of liquid biopsies, specifically on the use of extracellular vesicles as potential biomarkers in cancer detection, prognosis, and therapeutic monitoring! Are you a passionate and driven individual eager to contribute to cutting-edge cancer research? Read on and apply!

About your role

As a PhD candidate, you will be part of a team that aims to detect and monitor cancer through the analysis of tumor-derived extracellular vesicles (tdEVs) in the blood of cancer patients. This project focuses on the use of novel tumor-specific proteins and antibodies that target tdEVs for detection and characterization. You will first test such novel probes in EVs derived from cancer cell lines. You will then use the probes to label tdEVs in blood plasma of pancreatic and breast cancer patients. You will use state-of-the are methods, such as single-EV Flow Cytometry, super-resolution Fluorescence Microscopy and cryo-Electron Microscopy, to validate and quantify the presence of tdEVs in the blood of patients. You will design and test isolation assays using the novel probes to pull down the tdEVs and perform downstream characterization using mass spectrometry.

About you

  • MSc degree in Biomedical Sciences, Biomedical Engineering, or a related field.
  • Experience in culturing cells and performing standard molecular biology techniques.
  • Critical and creative thinking are part of your skillset.
  • You excel at both independent work and collaborative teamwork, with effective communication skills.
  • You master the English language well in written and oral form.
  • Motivated, driven and responsible.

Our offer

Getting better by breaking new ground; that’s our mission. This applies not only to healthcare, but also to our employees. In order to be able to continue to learn and develop, we offer internal and external training. You are also entitled to an end-of-year bonus (8,3%), holiday allowance, sports budget and bicycle scheme. Furthermore, as an employee of LUMC, you are also affiliated with the ABP pension fund. This means that 70% of your pension premium is paid by LUMC, leaving you with a higher net salary. Nice, right?


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