Post-doc position available – hepatocyte-derived exosomes

Position Information

Position Title Postdoctoral Fellow – IDSS
Vacancy ID PDS001881
Department SOP-Institute – 452202
Position Type Postdoctoral Scholar

Posting Details

Salary Range Dependent on Qualifications
Full-time/Part-time Full Time
If part-time, hours per week
FTE 1.0
Proposed Start Date 01/02/2018
Estimated Duration of Appointment 12 Months
Posting Open Date 11/17/2017
Posting Close Date
Open Until Filled Yes
Work Location Research Triangle Park, NC
Position Summary In 2016, the Institute for Drug Safety Sciences was recruited from The Hamner Institutes to join the Division of Pharmacotherapy and Experimental Therapeutics within the UNC Eshelman School of Pharmacy. The School of Pharmacy is the oldest of the health sciences academic programs at UNC-Chapel Hill and is the top ranked pharmacy school in the US.

The Institute for Drug Safety Sciences (IDSS) is located in Research Triangle Park, NC and directed by Dr. Paul Watkins, one of the leading experts in clinical drug-induced adverse reactions. Researchers within the IDSS utilize cutting-edge technologies to improve the understanding of toxicity mechanisms and mitigate the risk associated with adverse drug reactions. The IDSS has fostered alliances between the pharmaceutical industry, academia, and the FDA.

The translational pharmacogenomics group, led by Dr. Merrie Mosedale, is focused on the use of novel in vitro and in vivo platforms coupled with a systems biology approach to identify mechanisms and risk factors for adverse drug reactions.

Outstanding and motivated candidates are sought for a position exploring the utility of hepatocyte-derived exosomes to improve the prediction and understanding of drug-induced liver injury (DILI). The goal of this effort is to identify more sensitive, specific and mechanistic “biomarkers” for DILI to help improve patient safety and drug development. These studies are funded by a collaboration between the IDSS (Dr. Paul Watkins and Dr. Merrie Mosedale) and Janssen Pharmaceuticals as well as the Eshelman Institute for Innovation. Responsibilities will include design and implementation of in vitro studies to understand the influence of drug exposure and toxicity on the content and number of exosomes released from the liver as well as the ability of exosomes to alter the immune response of nonparenchymal cells. Data collection will utilize cutting-edge imaging and omics based approaches as well as molecular biology techniques. The successful candidate will have interactions with the investigative toxicology team at Janssen, as well as world class toxicologists, systems biologists, and cellular engineering experts at the UNC Eshelman School of Pharmacy. The initial appointment will be for one year, with the possibility of extension.

Educational Requirements Candidates must have a Pharm.D. or Ph.D. degree in a related field of study from an accredited institution.
Qualifications and Experience Ideal candidates will have a Ph.D. in biology, toxicology or pharmacology with 0-3 years of postdoctoral training.

Ideal candidates will have hands on experience conducting cell culture studies and be proficient in molecular biology techniques including protein and gene expression analysis.

Extensive prior experience with transcriptomics and proteomics analysis is desirable but not essential.

Equal Opportunity Employer The University of North Carolina at Chapel Hill is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to age, color, disability, gender, gender expression, gender identity, genetic information, race, national origin, religion, sex, sexual orientation, or status as a protected veteran.
Special Instructions For information on UNC Postdoctoral Benefits and Services click here
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Special Physical and Mental Requirements

Posting Contact Information

Department Contact Name and Title Rose Thorp
Department Contact Telephone or Email 919-966-9774
Postdoctoral Affairs Contact Information If you experience any problems accessing the system or have questions about the application process, please contact the University’s Equal Employment Opportunity office at (919)-962-1091 or send an email to

Please note: The Equal Employment Opportunity office will not be able to provide specific updates regarding position or application status.

Applicant Documents

Required Documents

  1. Curriculum Vitae / Resume
  2. Cover Letter
  3. List of References

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