AbbVie (NYSE:ABBV) is a global, research-based biopharmaceutical company formed in 2013 following separation from Abbott Laboratories. The company’s mission is to use its expertise, dedicated people and unique approach to innovation to develop and market advanced therapies that address some of the world’s most complex and serious diseases. AbbVie employs approximately 28,000 people worldwide and markets medicines in more than 170 countries.
“Proteomic and Transcriptomic Profiling of Exosomes in Patients with Autoimmune Diseases.”
The overall goal is to identify exosome derived biomarkers for RA and SLE using transcriptomic and proteomic approaches. Exosomes are nano-sized (30 to 200 nm) membrane vesicles that can be released by any cell and contain proteins and RNA and are present in all biological fluids. They are implicated in cell-to-cell communication in autoimmune disease pathogenesis. Thus, molecules important in disease processes are likely to be enriched in these structures. The central hypothesis is that the exosome profile reflects the underlying mechanism of disease, and therefore, in autoimmune diseases known for mechanistic heterogeneity, exosome analysis will identify patient subsets (TNF responders and non-responders in RA; subsets based on mechanism in SLE).
The primary expected outcome from this work is the identification of stratification biomarkers that can be used in clinical trials. In SLE we expect to find stratification biomarkers that, along with other “omic” data collected from the same patients, provide a stratification strategy for use in clinical trials. In RA, we expect to identify biomarkers that predict patient responses to anti-TNF treatment. Since exosomes are likely involved in disease pathogenesis, a secondary expected outcome is the identification of important cellular proteins and pathways that could be targeted therapeutically in the future Equal Opportunity Employer Minorities/Women/Veterans/Disabled
- PhD in molecular immunology or molecular biology is required.
- Although not required, bioinformatics experience is desired.
- Graduate of accredited and nationally ranked university
- Provide a narrative on why your academic training would qualify you for this position and why you have a sustained interest in this program
- Provide three letters of recommendation, one at least from your PI, and preferably, one from the Chair of your department or a member of the thesis committee
- Must be authorized to work in the U.S.
- Minimum graduate school GPA: 3.5Excellent problem-solving skills
- Excellent communication, leadership, and project management skills
- Proven track record of teamwork, adaptability, innovation, initiative, and integrity.
- Global mindset to thrive in a diverse culture and environment
Key AbbVie Competencies:
- Builds strong relationships with peers and cross functionally with partners outside of the team to enable higher performance.
- Learns fast, grasps the “essence” and can change the course quickly where indicated.
- Raises the bar and is never satisfied with the status quo.
- Creates a learning environment, open to suggestions and experimentation for improvement.
- Embraces the ideas of others, nurtures innovation and manages innovation to reality.