A three-year full time PhD Research Fellowship in Extracellular Vesicles and Immunotherapy (position code 1017) is available at the Department of Pharmacology, Institute of Clinical Medicine, The Faculty of Medicine, University of Oslo (UiO).
More about the position
The candidate will work on a project to develop extracellular vesicles from NK cells as nanovehicles for cancer therapy. The project is funded by the Norwegian Research Council’s NANO2021 progam. NK cells are increasingly exploited in immunotherapeutic therapies against cancers, due to their broad recognition of stress-induced self proteins on the surface of cancer cells. As NK cells have poor ability to infiltrate solid tumors, we will exploit the possibility to utilize NK-cell derived exosomes as a therapeutic product, with the hypothesis that NK-exosomes loaded with cytolytic cargo can infiltrate solid tumors. The work will involve design and production of an optimal NK-exosomal product, and testing using in vitro and in vivo cancer models. The work includes in vitro culture of primary human cells and cell lines, molecular biology, diverse immunological assays advanced flow cytometry, tumor spheroid models, and in vivo experimentation. The candidate is expected to collaborate with national/international partners and be prepared to travel.
The candidate will work in the research group of professor Marit Inngjerdingen at Department of Pharmacology, Institute of Clinical Medicine. The Inngjerdingen research group is focusing on innate lymphocytes and how they may control inflammation and cancer.
The applicant must, in collaboration with her/his supervisor, within 3 months after employment, have worked out a complete project description to be attached to the application for admission to the doctoral program.
The research fellow must take part in the Faculty of Medicine approved PhD program and is expected to complete the projectwithin the set fellowship period. The main purpose of the fellowship is research training leading to the successful completion of a PhD degree.
- Master degree-level education or equivalent within the fields of immunology, cell biology, or molecular biology.
- Experience with cell culture, flow cytometry, and/or immunological techniques is an advantage.
- Candidates must be highly motivated and structured, with excellent laboratory skills and good collaborative qualities.
- Candidates must have fluent oral and written communication skills in English.