Despite significant advancements in targeted or immune therapies, the survival rate of lung cancer continues to be low. This is largely a consequence of intrinsic or acquired resistance to a given treatment calling for a different treatment or medication approach. Thus, monitoring treatment responses by non-invasive methods, i.e. following the tumour in liquid biopsies, can significantly improve the outcome by providing the necessary feedback to the clinical decision point. During the past decade, tumour-derived extracellular vesicles (EVs) or exosomes have emerged as a potent source of such biomarkers. This project aims to validate a novel microchip-based technology for such analyses using clinical samples. The project also aims to improve the diagnostic precision by developing more accurate biomarkers through the analyses of individual exosomes by a state-of-the-art multiparametric single-exosome technology. The success of the project will lead to a general-purpose diagnostic and treatment monitoring platform applicable to different cancer types. Of the cross-disciplinary nature, the research requires close collaboration with oncologist, pathologists as well as expert from biotechnology and surface chemistry.
- A doctoral degree or an equivalent foreign degree, This eligibility requirement must be met no later than the time the employment decision is made.
- You should possess a strong background in experimental physics and engineering with a rich experience in exosome analysis, microfluidic concepts, electrical/electrochemical sensing in addition to a proven track record of high-quality scientific publications. Experience with fluorescence microscopy and atomic force microscopy is highly desired so is the experience in the development of experimental setup and systems for the characterization of biological materials. Good communication skills and command of written and spoken English are also a requirement.
- A doctoral degree or an equivalent foreign degree, obtained within the last three years prior to the application deadline
- Prior experience in electrokinetic based measurements as well as fluidic and electrokinetic simulations will be valuable. A proven record of successful multidisciplinary collaborations, teaching and supervision are also merits for the position. As a person you are ready to take on new challenges and work hard, have the capability to work independently, but are also a good team player, willing to support junior members. You thrive in and are willing to actively contribute to a dynamic, multidisciplinary and supportive work environment, nurturing collaboration, internationalization, diversity and equal opportunities. Great emphasis will be placed on personal competency