Promising noninvasive exosome therapy shows hope for healing stubborn scalp wounds

When it comes to treating difficult-to-heal wounds, particularly those that have resulted from cancer treatments like chemotherapy and radiation, finding effective solutions can be challenging. A recent case report from the Mayo Clinic has shed light on a new noninvasive therapy called Purified Exosome Product (PEP), which shows promising results for healing such stubborn wounds.

The Patient’s Journey

The case involves a man in his 60s who had been battling a high-grade angiosarcoma—a type of cancer—on his scalp. After undergoing intensive treatments including chemotherapy, chemoradiation, wide local excision (surgical removal of the tumor and some surrounding tissue), and reconstructive surgery with a latissimus dorsi free flap and a split-thickness skin graft, he was left with two persistent scalp wounds that refused to heal for over a year.

Innovative Treatment Approach

In 2022, the patient began a new treatment regimen involving PEP. This therapy utilizes purified exosomes, which are tiny vesicles secreted by cells that play a crucial role in cell communication and healing processes. The treatment included:

  • Débridement: Cleaning out the wound to remove dead tissue.
  • Application of PEP mixed with collagen (a protein that helps in wound healing) and fibrin (a protein involved in blood clotting and tissue repair).

The therapy was administered over a period of seven months, during which the patient received four applications each of collagen-PEP and fibrin-PEP.

Remarkable Results

The outcomes of this treatment were highly encouraging. The patient’s frontal wound, which was not measured quantitatively but assessed through photographs, completely healed. The more severely affected temporoparietal wound (on the side of the scalp) showed a remarkable 96% reduction in size.

Photographs of the wound were analyzed using ImageJ, an open-source software that helps standardize measurements, ensuring accurate tracking of healing progress. The patient experienced no adverse effects from the treatment and continues to show signs of ongoing healing.

Implications for Future Treatment

This case demonstrates the potential of PEP therapy as a safe and effective noninvasive treatment for wounds that do not respond well to conventional methods, particularly in patients who may not be suitable candidates for further surgical interventions. The success of PEP in promoting significant wound healing offers hope for patients dealing with similar challenges, providing an alternative to more invasive procedures.


The use of Purified Exosome Product (PEP) therapy represents a significant advancement in the treatment of nonhealing wounds, especially for those affected by previous cancer treatments. This innovative approach not only accelerates the healing process but also minimizes the need for additional surgeries, thereby improving the quality of life for patients with challenging wound care needs. As more research and clinical trials are conducted, PEP therapy could become a standard option for managing difficult-to-heal wounds, offering new hope and healing for patients around the world.

Pumford AD, Staricha KL, Kunkel ET, Armstrong MF, Behfar A, Van Abel KM. (2024) Exosome Therapy for a Nonhealing Scalp Wound Following Chemoradiation and Surgical Therapy. Mayo Clin Proc 99(6):1006-1012. [article]

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