Coronary artery disease leading to myocardial infarction (“heart attack”) is a major cause of death worldwide . After a heart attack, the myocardium is unable to regenerate, therefore, the heart remains permanently scarred and unable to carry out its function, which eventually leads to heart failure. Current therapies are palliative, aimed at unburdening the failing heart, or heart transplantation. Reprogramming adult cardiomyocytes to a proliferative state, via the use of non-inmunogenic EVs is a potential therapeutic approach to restore lost heart muscle, resolve scarring and prevent heart failure progression.
Regenerative potential of epicardium-derived extracellular vesicles mediated by conserved miRNA transfer
Villa Del Campo C, Liaw NY, Gunadasa-Rohling M, Matthaei M, Braga L, Kennedy T, Salinas G, Voigt N, Giacca M, Zimmermann WH, Riley PR. (2021) Regenerative potential of epicardium-derived extracellular vesicles mediated by conserved miRNA transfer. Cardiovasc Res [Epub ahead of print]. [abstract]