Use of exosomes as biomarkers in non-small cell lung cancer (NSCLC) is an intriguing approach in the liquid-biopsy era. Exosomes are nano-sized vesicles with membrane-bound proteins that reflect their originating cell. Prognostic biomarkers are needed to improve patient selection for ...Read More »
Exosomal proteins as potential diagnostic markers in advanced non-small cell lung carcinoma
Lung cancer is one of the leading causes of cancer-related death. At the time of diagnosis, more than half of the patients will have disseminated disease and, yet, diagnosing can be challenging. New methods are desired to improve the diagnostic ...Read More »
Specific g-force/k factor usage during differential centrifugation greatly influences the purity and yield of exosomes.
Cells release a mixture of extracellular vesicles, amongst these exosomes, that differ in size, density and composition. The standard isolation method for exosomes is centrifugation of fluid samples, typically at 100,000×g or above. Knowledge of the effect of discrete ultracentrifugation ...Read More »
Exosome-mediated secretion of tumor-suppressor miRNA activates metastatic cascade
Exosomes are small secreted vesicles that can transfer their content to recipient cells. In cancer, exosome secretion has been implicated in tumor growth and metastatic spread. In this study, researchers at Aarhus University Hospital, Denmark explored the possibility that exosomal ...Read More »