The mechanisms of melanoma metastasis have been the subject of extensive research for decades. Improved diagnostic and therapeutic strategies are...
Read More »Role of tumor-derived exosomes in cancer metastasis
The highlights of cancer research include the discovery of exosomes, which are small (30-100 nm) sized vesicular nanoparticles released virtually by all cells. Tumor-derived exosomes (TDEs) are notoriously known for orchestrating the invasion-metastasis cascade via systemic pathways...
Read More »UCV researchers discover the influence of exosomes on age-related macular degeneration
Researchers of the Neurobiology and Neurophysiology team of the Medicine Faculty at Valencia Catholic University (UCV), headed by Jorge Bacia, have discovered that exosomes – microscopic extracellular vesicles that are released by all cells...
Read More »Bioengineered extracellular vesicle-mimetic nanovesicles can serve as a powerful instrument to effectively deliver lncRNA
Diabetic wounds, one of the most enervating complications of diabetes mellitus, affect millions of people worldwide annually. Vascular insufficiency, caused by hyperglycemia, is one of the primary causes...
Read More »The origin and functions of exosomes in cancer
Exosomes are nanovesicles having a maximum size of 150 nm and is a newly emerging focus in various fields of research. Its role in cargo trafficking along with its differential expression is associated with the disrupted homeostasis and provides an opportunity ...
Read More »Replenishing exosomes from older bone marrow cells with microRNA inhibits myeloma-related angiogenesis
The study of bone marrow stromal cells (BMSCs) and the exosomes they secrete is considered promising for cancer therapy. However, little is known about the effect of donor age on BMSCs...
Read More »Exosomes mend a broken heart
Stem cell transplantation therapy is a promising adjunct for regenerating damaged heart tissue; however, only modest improvements in cardiac function have been observed due to poor survival of transplanted cells in the ischemic heart. Therefore, there remains an unmet need ...
Read More »Using RGD-engineered exosomes for enhanced targeting ability and synergistic therapy toward angiogenesis
Promoted therapeutic angiogenesis is a major objective in the area of regenerative medicine, and sufficient vascularization of artificial tissues or organs is one of the main difficulties for the realization of tissue engineering methods. The identification of new kinds of ...
Read More »Glioblastoma Exosomes for Therapeutic Angiogenesis
Peripheral ischemia as a result of occlusive vascular disease is a widespread problem in patients over the age of 65. Angiogenic therapies that can induce microvascular growth have great potential for providing a long lasting solution for patients with ischemia ...
Read More »Exosomes from Plasmodium-infected Hosts Inhibit Tumor Angiogenesis
A research group led by Prof. CHEN Xiaoping from the Guangzhou Institutes of Biomedicine and Health (GIBH) of Chinese Academy of Sciences revealed a new mechanism about exosomes from Plasmodium-infected hosts inhibit tumor angiogenesis. The study was published in Oncogenesis. Malaria infection has been ...
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