miRNAs are master regulators of signalling pathways critically involved in asthma and are transferred between cells in extracellular vesicles (EV). Researchers at the University of Groningen aimed to...
Read More »Exosomes – a new approach to asthma pathology
Asthma is a chronic inflammatory disease of the airways with a complex pathophysiology, making the development of diagnostic and therapeutic tools a challenge. Exosomes are extracellular membranous nanovesicles implicated in intercellular communication. Exosome composition and cargo are highly heterogeneous depending ...
Read More »A novel mechanism of cell-cell communication involving exosomal transfer of mitochondria
Chronic inflammation involving both innate and adaptive immune cells is implicated in the pathogenesis of asthma. Intercellular communication is essential for driving and resolving inflammatory responses in asthma. Emerging studies suggest that...
Read More »Exosomes and MicroRNAs – Novel Modulators of Asthma and Allergy
Intercellular communication is crucial to the immune system response. In the recent years, the discovery of exosomes has changed the way immune response orchestration was understood. Exosomes are able to operate as independent units that act as mediators in both ...
Read More »Exosomes in the nose induce immune cell trafficking and harbour an altered protein cargo in chronic airway inflammation
Exosomes are nano-sized extracellular vesicles participating in cell-to-cell communication both in health and disease. However, the knowledge about the functions and molecular composition of exosomes in the upper airways is limited. The aim of the current study was therefore to ...
Read More »Intercellular Communication by Extracellular Vesicles and Their MicroRNAs in Asthma
Extracellular vesicles (EVs) such as exosomes and microvesicles are phospholipid bilayer-enclosed vesicles that are recognized as novel tools for intercellular communications and as biomarkers for several diseases. They contain various DNAs, proteins, mRNAs, and microRNAs (miRNAs) that have potential diagnostic ...
Read More »Elucidating the role of exosomes in bronchial asthma
Ankur Kulshreshtha*, Tanveer Ahmad, Anurag Agrawal, Balaram Ghosh *Corresponding author: Ankur Kulshreshtha Molecular Immunogenetics Laboratory, Institute of Genomics and Integrative Biology, Delhi, India F1000Posters 2012, 3: 426 (poster) [English] Poster [1.08 MB] | Recommended by F1000Prime | Presented at: 1st ...
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