Extracellular vesicles (EVs) have garnered much attention as key mediators of intercellular communication within the tumor microenvironment (TME) as well as at distinct metastatic sites...
Read More »Progress in extracellular vesicle biology and their application in cancer medicine
Under the broader category of extracellular vesicles (EVs), exosomes are now well recognized for their contribution and potential for biomedical research. During the last ten years, numerous technologies for purification and characterization of EVs have been developed. This enhanced knowledge has ...
Read More »Inside(sight) of tiny communicator: exosome biogenesis, secretion, and uptake
Discovered in the late 1980s as an extracellular vesicle of endosomal origin secreted from reticulocytes, exosomes recently gained scientific attention due to its role in intercellular communication. Exosomes have now been identified to carry...
Read More »Mechanisms associated with biogenesis of exosomes in cancer
Intercellular communication between cellular compartments within the tumor and at distant sites is critical for the development and progression of cancer. Exosomes have emerged as potential regulators of intracellular communication in cancer. Exosomes are nanovesicles released by cells that contain ...
Read More »Basic and clinical aspects of extracellular vesicles
The past decade has witnessed an exponential development in the field of extracellular vesicles. Sporadic observations have reached a critical level and the scientific community increasingly...
Read More »Exosome biogenesis and biological function in response to viral infections
Exosomes are extracellular vesicles that originate as intraluminal vesicles during the process of multivescular body formation. Exosomes mediate intercellular transfer of functional proteins, lipids, and RNAs. The investigation into the formation and role of exosomes in viral infections is still ...
Read More »Exosomes – their biogenesis and role in inter-cellular communication, tumor microenvironment and cancer immunotherapy
Exosomes are extracellular vesicles ranging from 30 to 150 nm in diameter that contain molecular constituents of their host cells. They are released from different types of cells ranging from immune to tumor cells and play an important role in intercellular...
Read More »Shedding light on the cell biology of extracellular vesicles
Extracellular vesicles are a heterogeneous group of cell-derived membranous structures comprising exosomes and microvesicles, which originate from the endosomal system or which are shed from the plasma membrane, respectively. They are present in biological fluids and are involved in multiple ...
Read More »Exosomes – Origins and Therapeutic Potential for Neurodegenerative Disease
Exosomes, small lipid bilayer vesicles, are part of the transportable cell secretome that can be taken up by nearby recipient cells or can travel through the bloodstream to cells in distant organs. Selected cellular cytoplasm containing proteins, RNAs, and other ...
Read More »Grant Funding Opportunity – Exosomes: From Biogenesis and Secretion to the Early Pathogenesis of Alzheimer’s Disease (R01)
Participating Organization(s) – National Institutes of Health (NIH) Components of Participating Organizations – National Institute on Aging (NIA) Funding Opportunity Title – Exosomes: From Biogenesis and Secretion to the Early Pathogenesis of Alzheimer’s Disease (R01) – Activity Code – R01 ...
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