Tag Archives: biomarker discovery

The recent discovery of extracellular RNAs in blood, including RNAs in extracellular vesicles (EVs), combined with low input RNA sequencing advances have enabled scientists to investigate their role in...

The preservation of nucleic acids from clinical samples is critical to facilitate accurate molecular diagnosis. The use of a paper matrix, Flinders Technology Associates (FTA) Elute cards, to archive DNA and viral RNA is well-documented. However, the feasibility of FTA ...

San Francisco, CA | Translational Medicine Job Summary This position will be responsible for biomarker discovery and diagnostic development for rucaparib and other Clovis programs. This positon will work effectively with Translational Medicine, Biostatistics, Clinical Development, Regulatory, Clinical Operation, and ...

Circulating exosomes provide a promising approach to assess novel and dynamic biomarkers in human disease, due to their stability, accessibility and representation of molecules from source cells. However, this potential has been stymied by lack of approaches for molecular profiling ...

Early and accurate assessment of radiation injury by radiation-responsive biomarkers is critical for triage and early intervention. Biofluids such as urine and serum are convenient for such analysis, recent research also suggests that exosomes are a reliable source of biomarkers ...

While the Visual Impairment and Intracranial Pressure (VIIP) syndrome observations have focused on ocular symptoms, spaceflight has been also associated with a number of other performance and neurologic signs, such as headaches, cognitive changes, vertigo, nausea, sleep/circadian disruption and mood ...

In recent years, biomarker discovery based on extracellular microRNAs (miRNAs), especially exosome miRNAs, has drawn wide attention. While exosome isolation and identification technologies are increasingly sophisticated, the preanalytical process of exosome miRNAs seems to be no longer a crucial problem. ...

The Hamner-University of North Carolina Institute for Drug Safety Sciences (IDSS) is dedicated to understanding, predicting, and preventing adverse reactions to drugs. The IDSS is located in Research Triangle Park, NC and directed by Paul Watkins, M.D., one of the ...

A brief summary of the main features of extracellular vesicles, a joint terminology for exosomes, microvesicles, and apoptotic vesicles. These vesicles are in the center of interest in biology and medical sciences, and form a very active field of research. ...

Urinary exosomes are nanovesicles (40-100 nm) of endocytic origin that are secreted into the urine when a multivesicular body fuses with the membrane of cells from all nephron segments. Interest in urinary exosomes intensified after the discovery that they contain ...