Biomedical scientists at LMU have found a new marker in the blood of Covid-19 patients. It furnishes insights into the course and development of the disease and could lead to better diagnoses...
Read More »Extracellular vesicles as a source of prostate cancer biomarkers in liquid biopsies: a decade of research
Urologic cancers are a heterogeneous group of tumors, some of which have poor prognosis. This is partly due to the unavailability of specific and sensitive diagnostic techniques and monitoring tests, ideally non- or minimally invasive. Hence, liquid biopsies are promising ...
Read More »Acoustofluidic separation enables early diagnosis of traumatic brain injury based on circulating exosomes
Traumatic brain injury (TBI) is a global cause of morbidity and mortality. Initial management and risk stratification of patients with TBI is made difficult by the relative insensitivity of screening radiographic studies as well as by the absence of a ...
Read More »Extracellular RNAs as potential biomarkers for cancer
The discovery that all cells secrete extracellular vesicles (EVs) to shuttle proteins and nucleic acids to recipient cells suggested they play an important role in intercellular communication. EVs are widely distributed in many body fluids, including blood, cerebrospinal fluid, urine ...
Read More »Exosomes in hypoxia-induced remodeling of the tumor microenvironment
Exosomes are structurally and functionally pleiotropic nano-sized (∼30–150 nm in diameter) extracellular vesicles (EVs) with endosomal origin. These vesicles are secreted by almost all cells and play a significant role in intercellular communication...
Read More »A microfluidic device for detection and isolation of lung cancer-specific exosomes from urine
Exosomes, derived from various biofluids, may serve as potential biomarkers for cancer early detection. Nevertheless, exosome clinical translation remains...
Read More »Exosomes – from garbage bins to translational medicine
Exosomes are lipid bilayer-enclosed vesicles of endosomal origin, which initially considered as garbage bins to dispose unwanted cellular components, but they are now emerged as an...
Read More »Circulating extracellular vesicles for the diagnosis and dynamic risk profiling of alcoholic hepatitis
Alcoholic hepatitis (AH) is diagnosed by clinical criteria, although several objective scores facilitate risk stratification. Extracellular vesicles (EVs) have emerged as novel biomarkers for many diseases and are also implicated in the pathogenesis of AH...
Read More »Isolation of DNA from exosomes
Exosomes are small extracellular vesicles released by prokaryotic and eukaryotic cells with a crucial role in cell-to-cell communication in both physiological and pathological conditions. Exosomes contain and transfer active biomolecules, including nucleic acids..
Read More »Inclusion biogenesis, methods of isolation and clinical application of human cellular exosomes
Exosomes are a heterogenous subpopulation of extracellular vesicles 30–150 nm in range and of endosome-derived origin. Despite more than 30 years of research that followed their definition and indicated their important role in cellular...
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