Non-coding RNA (ncRNA) species have emerged in as molecular fingerprints and regulators of brain tumor pathogenesis and progression. While changes in ncRNA levels have been traditionally regarded as...
Read More »Extracellular Vesicles in Brain Tumors and Neurodegenerative Diseases
Extracellular vesicles (EVs) can be classified into apoptotic bodies, microvesicles (MVs), and exosomes, based on their origin or size. Exosomes are the smallest and best characterized vesicles which derived from the endosomal system. These vesicles are released from many different ...
Read More »DNA sequences within glioma-derived exosomes can cross the intact blood-brain barrier
Tumor-cell-secreted extracellular vesicles (EVs) can cross the disrupted blood-brain barrier (BBB) into the bloodstream. However, in certain gliomas, the BBB remains intact, which might limit EVs release. To evaluate the ability of tumor-derived EVs to cross the BBB, researchers at ...
Read More »ExRNA in Biofluids as Biomarkers for Brain Tumors
EV RNAs have tremendous clinical potential as diagnostic, subtype-defining, and prognostic biomarkers in GBM. The identification of new EV RNA targets and validation of existing EV RNA targets will be accelerated by large-scale biorepositories established for clinic sample warehousing and ...
Read More »Liquid biopsy of cerebrospinal fluid – more effective at policing of brain tumors
VHIO leads research proposing cerebrospinal fluid as liquid biopsy for the early diagnosis, prognosis, therapeutic management and tracking of brain cancer Reported in the journal Nature Communications, the Vall d’Hebron Institute of Oncology´s (VHIO) Gene Expression and Cancer Group, led ...
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