Extracellular vesicles, including exosomes, are released by all cells, including those of the nervous system. Capable of delivering lipid, protein and nucleic acids to both nearby and distal cells...
Read More »Delivering multiple sclerosis drugs to the brain in extracellular vesicles
Researchers from the department of anatomy and cell biology in the UIC College of Medicine have received a seed grant to develop a new drug...
Read More »Exosomes as a biomarker platform for detecting brain tumors
High-grade glial brain tumors are often characterized by an elevated expression of the tumorigenic epidermal growth factor receptor variant III ( EGFRvIII). researchers from the Apollo Hospitals Educational and Research Foundation sought to establish a clinically adaptive protocol as a noninvasive ...
Read More »How the injured brain tells the body it’s hurt
Johns Hopkins researchers say they have identified a new way that cells in the brain alert the rest of the body to recruit immune cells when the brain is injured. The work was completed in mouse models that mimic infection, ...
Read More »A Method for Isolation of Extracellular Vesicles and Characterization of Exosomes from Brain Extracellular Space
Extracellular vesicles (EV), including exosomes, secreted vesicles of endocytic origin, and microvesicles derived from the plasma membrane, have been widely isolated and characterized from conditioned culture media and bodily fluids. The difficulty in isolating EV from tissues, however, has hindered ...
Read More »NASA recruiting patients for CSF exosome RNA profiling to study brain gene expression signatures
While the Visual Impairment and Intracranial Pressure (VIIP) syndrome observations have focused on ocular symptoms, spaceflight has been also associated with a number of other performance and neurologic signs, such as headaches, cognitive changes, vertigo, nausea, sleep/circadian disruption and mood ...
Read More »Extracellular Vesicles: Goodies for the Brain?
from Neuropsychopharmacology Reviews by Eva-Maria Krämer-Albers and Wen Ping Kuo-Elsne Brain homeostasis requires extensive signaling and information exchange between all types of neural cells, including neurons and glia. Recent studies indicated a pivotal role of extracellular vesicles (EVs) in communication between neural ...
Read More »Brainy exosomes – a novel pool for biomarker discovery in human CSF
Exosomes, endocytic vesicles ranging in size from 40–100nm, have revolutionized the field of cell–cell communication. Although they were first described in the 1980s, detailed analysis of exosome biogenesis, composition and function has occurred primarily within the past decade. The significance ...
Read More »Extracellular miR-21 Shown to Lead to Neurotoxicity in SIV Neurological Disease
Recent studies have found that extracellular vesicles (EVs) play an important role in normal and disease processes. In their recent study, a team of scientists led by researchers from the University of Nebraska Medical Center isolated and characterized EVs from ...
Read More »Study Says Blood Test for Brain Insulin Resistance Accurately Predicts Alzheimer’s Disease Risk
Technology May Be Useful in Measuring the Prognosis and Treatment of Alzheimer’s Disease October 30, 2014 08:15 AM Eastern Daylight Time ALISO VIEJO, Calif.–(BUSINESS WIRE)–Brain insulin resistance is an abnormality in Alzheimer’s disease that contributes to neural cell damage and ...
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