Breast cancer is a leading cause of cancer mortality in women. Despite advance in its management, the identification of new options for early stage...
Read More »Microfluidic human liver-chip to investigate the roles of breast cancer-derived extracellular vesicles
A new study, affiliated with UNIST has unveiled the mechanisms involved in the liver metastasis of breast cancer, thanks to the three-dimensional (3D) organ-on-a-chip that mimics human liver functions...
Read More »Breast cancer cells use message-carrying extracellular vesicles to send oncogenic stimuli to neighboring normal cells
According to a study by The Wistar Institute, breast cancer cells starved for oxygen send out messages that induce oncogenic changes in surrounding normal epithelial cells. These messages are packaged into particles called extracellular vesicles (EVs) and reprogram mitochondrial shape ...
Read More »Tear exosomes – a potential source of diagnostic and prognostic biomarkers for metastatic breast cancer
Exosomes are produced by normal and cancer cells. Exosomes are found in the serum of cancer patients and have been used for diagnosis and prognosis. Recently tears from non-cancer patients have been found to contain exosomes. In the present report ...
Read More »Anticancer effect of physical activity is mediated by modulation of extracellular microRNA in blood
Researchers at the University of Genoa aimed to explore the involvement of miRNAs in beneficial effects exerted by physical activity in breast cancer prevention.The levels of extracellular miRNAs were evaluated in blood plasma before and after structured...
Read More »Isolation of breast cancer-derived nanovesicles by immunomagnetic separation and electrochemical immunosensing
Exosomes are cell-derived nanovesicles released into biological fluids, which are involved in cell-to-cell communication. The analysis of the content and the surface of the exosomes allow conclusions about the...
Read More »Microfluidic device for on-chip isolation and detection of circulating exosomes in blood of breast cancer patients
Tumor-derived circulating exosomes have been recognized as a promising biomarker source for cancer diagnosis via a less invasive procedure. The integration of isolation and detection of exosomes in...
Read More »Genetically engineered cell-derived nanoparticles for targeted breast cancer immunotherapy
Exosomes are nanosized membranous vesicles secreted by a variety of cells. Due to their unique and pharmacologically important properties, cell-derived exosome nanoparticles have drawn significant interest for drug development. By genetically modifying exosomes with two distinct types of surface-displayed monoclonal ...
Read More »Recent advancements in the study of breast cancer exosomes as mediators of intratumoral communication
Breast cancer is a heterogeneous disease, with a morbidity rate of 27.8% and a mortality rate of 15% among women population worldwide. Understanding how this cancer develops and the mechanisms behind tumor progression and chemoresistance is of utmost importance. Exosomes ...
Read More »Exosomal miRNAs from highly metastatic cells can induce metastasis in non-metastatic cells
Breast cancer is a high prevalence cancer among women worldwide. 15-20% of breast cancer cases are triple-negative with a poor prognosis. miRNA aberrant expression is one of the reasons of cancer development and metastasis. Exosomes are vesicles...
Read More »