Exosomes are a subset of membrane-bound extracellular vesicles with diameters ranging from 30 to 100 nm. Exosomes enclose a variety of molecules...
Read More »Detection of single-point mutation in extracellular vesicle-associated RNAs with molecular beacons
Detection of specific extracellular RNAs has been developed for non-invasive cancer diagnosis. However, accurate and efficient identification of RNAs with single-point mutation in cancer cells-derived extracellular vesicles (EVs) is challenging. Researchers...
Read More »Recent advances in exosomal protein detection via liquid biopsy biosensors for cancer screening, diagnosis, and prognosis
Current cancer diagnostic methods are challenged by low sensitivity, high false positive rate, limited tumor information, uncomfortable or invasive procedures, and high cost. Liquid biopsy that analyzes circulating...
Read More »Exosomes in cancer: small particle, big player
Exosomes have emerged as a novel mode of intercellular communication. Exosomes can shuttle bioactive molecules including proteins, DNA, mRNA, as well as non-coding RNAs from one cell to another, leading to the exchange of genetic information and reprogramming of the ...
Read More »On-chip detection of exosomal RNA for cancer study and diagnosis
There has been increasing evidence that micro and messenger RNA derived from exosomes play important roles in pancreatic and other cancers. In this work, researchers from the University of Notre Dame present a microfluidics-based approach to the analysis of exosomal RNA ...
Read More »New ‘lab-on-a-chip’ could revolutionize early diagnosis of cancer
LAWRENCE — Scientists have been laboring to detect cancer and a host of other diseases in people using promising new biomarkers called “exosomes.” Indeed, Popular Science magazine named exosome-based cancer diagnostics one of the 20 breakthroughs that will shape the world ...
Read More »Automated rapid and reproducible exosome extraction from clinical samples
Exosome-mediated signal transportation plays a variety of critical roles in cancer progression and metastasis. From the aspect of cancer diagnosis, circulating exosomes are ideal resources of biomarkers because molecular features of tumor cells are transcribed on them. However, isolating pure ...
Read More »Researchers find speedy, efficient method to detect colorectal cancer
from The Asahi Shimbun Researchers have developed a test to detect early-stage colorectal cancer that is quicker and more precise than conventional methods, and requires only a small blood sample. Led by Takahiro Ochiya, chief researcher of the National Cancer ...
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