Numerous studies have shown that exosomes are closely related to the pathogenesis of various diseases, especially cancers. Therefore, a rapid and sensitive method for exosome detection will be of...
Read More »Decoy exosomes as a novel biologic reagent to antagonize inflammation
Exosomes are ubiquitous naturally secreted stable nanovesicles that can be engineered to target and deliver novel therapeutics to treat a host of human...
Read More »A catalytic molecule machine-driven biosensing method for amplified electrochemical detection of exosomes
Exosomes that carry abundant information have attracted increasing attention as potent biomarkers of liquid biopsy and ideal candidates for early diagnosis and treatment of cancers. Shanghai University...
Read More »Optimisation of imaging flow cytometry for the analysis of single extracellular vesicles
Extracellular vesicles (EVs) mediate targeted cellular interactions in normal and pathophysiological conditions and are increasingly recognised as potential biomarkers, therapeutic agents and drug delivery vehicles. Based on their size and biogenesis, EVs are classified as exosomes, microvesicles and apoptotic bodies. ...
Read More »Detection and Characterization of Extracellular Vesicles by Transmission and Cryo-Transmission Electron Microscopy
Transmission electron microscopy (TEM) and transmission scanning electron Microscopy (TSEM), which denotes application of a scanning electron microscope (SEM) in the transmission mode, have been used to detect and characterize particles down to an imaging resolution of ~1 nm. In ...
Read More »Chemically edited exosomes purified by microfluidic device for active targeted drug delivery to tumor cells
Exosomes, which are lipid membrane-bound nanovesicles (50-150 nm in diameter), have great potential for non-invasive molecular diagnostics and represent a novel therapeutic delivery system but are limited by poor targeting ability and a lack of efficient isolation techniques. Here, researchers ...
Read More »Northwestern researchers develop a platform for enhanced RNA cargo loading into extracellular vesicles
Extracellular vesicles (EVs) mediate intercellular communication through transfer of RNA and protein between cells. Thus, understanding how cargo molecules are loaded and delivered by EVs is of central importance for elucidating the biological roles of EVs and developing EV-based therapeutics. ...
Read More »Development of Exosome Surface Display Technology in Living Human Cells
Surface display technology is an emerging key player in presenting functional proteins for targeted drug delivery and therapy. Although a number of technologies exist, a desirable mammalian surface display system is lacking. Exosomes are extracellular vesicles that facilitate cell-cell communication ...
Read More »